Abstract The past decade has witnessed an explosive deployment of wireless technologies. The vast expansion of connectivity by wireless networks combined with the rapid evolution of highly-programmable mobile devices, have had strong impacts on our life. Security has arisen as a major concern in wireless networks. Many crypto-based solutions have been developed to provide the first line of defense, ranging from fundamental security services such as authentication and privacy, to the protection of the infrastructure and the various network components. Recently, cross-layer security enhancement has emerged as a promising approach to the unique challenge facing mobile wireless networks, i.e. mobile devices may be compromised (stolen, reverse engineered, or forged). The idea is to extract unique and unforgeable information from wireless communications or mobile devices and supply such information to other layers for enhanced security. In this talk, we will discuss this transition and several promising research directions. Speaker's Bio Wenjing Lou received her Ph.D. in Electrical and Computer Engineering from University of Florida. She is currently an associate professor in the Computer Science department at Virginia Polytechnic Institute and State University, and a co-director of the Complex Networks and Security Research (CNSR) lab. Prior to joining Virginia Tech in 2011, she was on the faculty of Worcester Polytechnic Institute from 2003 to 2011. Her current research interests include wireless network security and data security and privacy in cloud computing. She is currently serving on the editorial boards of IEEE Transactions on Parallel and Distributed Systems and IEEE Wireless Communications Letters. She has served as TPC co-chair for the security symposium of several IEEE conferences, including IEEE Globecom 2007, IEEE ICCCN 2009, IEEE ICC 2010, IEEE PIMRC 2011, and IEEE Globecom 2012. She is the mini-conference co-chair for IEEE INFOCOM 2013, and the panel co-chair for IEEE INFOCOM 2014. She serves as TPC Area Chair for IEEE INFOCOM 2013 & 2014, IEEE ICNP 2013, and IEEE SECON 2014. She is the lead co-founder and TPC co-chair for the First IEEE Conference on Communications and Network Security (IEEE CNS), held in Washington DC in October 2013.