Biophysical Journal

Biophysical Journal - Table of Contents - Volume 106 Issue 1, 07 January 2014
  • Nanoscopy of Filamentous Actin in Cortical Dendrites of a Living Mouse
    [Jan 2014]

    Katrin I. Willig, Heinz Steffens, Carola Gregor, Alexander Herholt, Moritz J. Rossner, Stefan W. Hell. We demonstrate superresolution fluorescence microscopy (nanoscopy) of protein distributions in a mammalian brain in vivo. Stimulated emission depletion microscopy reveals the morphology of the fil....
    Categories: Journal Articles
  • Energetic View on Membrane Pore Formation
    [Jan 2014]

    Martina Pannuzzo, Rainer A. Böckmann.
    Categories: Journal Articles
  • Temperature Cycles Unravel the Dynamics of Single Biomolecules
    [Jan 2014]

    Haifeng Yuan, Michel Orrit.
    Categories: Journal Articles
  • Actomyosin Pulls to Advance the Nucleus in a Migrating Tissue Cell
    [Jan 2014]

    Jun Wu, Ian A. Kent, Nandini Shekhar, T.J. Chancellor, Agnes Mendonca, Richard B. Dickinson, Tanmay P. Lele. The cytoskeletal forces involved in translocating the nucleus in a migrating tissue cell remain unresolved. Previous studies have variously implicated actomyosin-generated pushing or pulling force....
    Categories: Journal Articles
  • A Simple Force-Motion Relation for Migrating Cells Revealed by Multipole Analysis of Traction Stress
    [Jan 2014]

    Hirokazu Tanimoto, Masaki Sano. For biophysical understanding of cell motility, the relationship between mechanical force and cell migration must be uncovered, but it remains elusive. Since cells migrate at small scale in dissip....
    Categories: Journal Articles
  • Ligand Mobility Regulates B Cell Receptor Clustering and Signaling Activation
    [Jan 2014]

    Christina Ketchum, Heather Miller, Wenxia Song, Arpita Upadhyaya. Antigen binding to the B cell receptor (BCR) induces receptor clustering, cell spreading, and the formation of signaling microclusters, triggering B cell activation. Although the biochemical pathw....
    Categories: Journal Articles
  • Switching of Swimming Modes in Magnetospirillium gryphiswaldense
    [Jan 2014]

    M. Reufer, R. Besseling, J. Schwarz-Linek, V.A. Martinez, A.N. Morozov, J. Arlt, D. Trubitsyn, F.B. Ward, W.C.K. Poon. The microaerophilic magnetotactic bacterium Magnetospirillum gryphiswaldense swims along magnetic field lines using a single flagellum at each cell pole. It is believed that this magnetotac....
    Categories: Journal Articles
  • Direct Measurement of Helical Cell Motion of the Spirochete Leptospira
    [Jan 2014]

    Shuichi Nakamura, Alexander Leshansky, Yukio Magariyama, Keiichi Namba, Seishi Kudo. Leptospira are spirochete bacteria distinguished by a short-pitch coiled body and intracellular flagella. Leptospira cells swim in liquid with an asymmetric morphology of the cell bo....
    Categories: Journal Articles
  • Thermodynamic Modeling of Variations in the Rate of RNA Chain Elongation of E. coli rrn Operons
    [Jan 2014]

    David Fange, Harriet Mellenius, Patrick P. Dennis, Måns Ehrenberg. Previous electron-microscopic imaging has shown high RNA polymerase occupation densities in the 16S and 23S encoding regions and low occupation densities in the noncoding leader, spacer, and trail....
    Categories: Journal Articles
  • Border Forces and Friction Control Epithelial Closure Dynamics
    [Jan 2014]

    Olivier Cochet-Escartin, Jonas Ranft, Pascal Silberzan, Philippe Marcq. We study the closure dynamics of a large number of well-controlled circular apertures within an epithelial monolayer, where the collective cell migration responsible for epithelization is triggere....
    Categories: Journal Articles
  • Mapping the Energy and Diffusion Landscapes of Membrane Proteins at the Cell Surface Using High-Density Single-Molecule Imaging and Bayesian Inference: Application to the Multiscale Dynamics of Glycine Receptors in the Neuronal Membrane
    [Jan 2014]

    Jean-Baptiste Masson, Patrice Dionne, Charlotte Salvatico, Marianne Renner, Christian G. Specht, Antoine Triller, Maxime Dahan. Protein mobility is conventionally analyzed in terms of an effective diffusion. Yet, this description often fails to properly distinguish and evaluate the physical parameters (such as the membrane....
    Categories: Journal Articles
  • Theoretical Analysis of Membrane Tension in Moving Cells
    [Jan 2014]

    Yonatan Schweitzer, Arnon D. Lieber, Kinneret Keren, Michael M. Kozlov. Lateral tension in cell plasma membranes plays an essential role in regulation of a number of membrane-related intracellular processes and cell motion. Understanding the physical factors generatin....
    Categories: Journal Articles
  • The Autodepalmitoylating Activity of APT Maintains the Spatial Organization of Palmitoylated Membrane Proteins
    [Jan 2014]

    Nachiket Vartak, Bjoern Papke, Hernan E. Grecco, Lisaweta Rossmannek, Herbert Waldmann, Christian Hedberg, Philippe I.H. Bastiaens. The localization and signaling of S-palmitoylated peripheral membrane proteins is sustained by an acylation cycle in which acyl protein thioesterases (APTs) depalmitoylate mislocalized palmitoylat....
    Categories: Journal Articles
  • Evidence for Two Extremes of Ciliary Motor Response in a Single Swimming Microorganism
    [Jan 2014]

    Ilyong Jung, Thomas R. Powers, James M. Valles. Because arrays of motile cilia drive fluids for a range of processes, the versatile mechano-chemical mechanism coordinating them has been under scrutiny. The protist Paramecium presents opp....
    Categories: Journal Articles
  • Furrow Constriction in Animal Cell Cytokinesis
    [Jan 2014]

    Hervé Turlier, Basile Audoly, Jacques Prost, Jean-François Joanny. Cytokinesis is the process of physical cleavage at the end of cell division; it proceeds by ingression of an acto-myosin furrow at the equator of the cell. Its failure leads to multinucleated cell....
    Categories: Journal Articles
  • How Cells Feel: Stochastic Model for a Molecular Mechanosensor
    [Jan 2014]

    Matteo Escudé, Michelle K. Rigozzi, Eugene M. Terentjev. Understanding mechanosensitivity (i.e., how cells sense the stiffness of their environment) is very important, yet there is a fundamental difficulty in understanding its mechanism: to measure an e....
    Categories: Journal Articles
  • Mutations in the S6 Gate Isolate a Late Step in the Activation Pathway and Reduce 4-AP Sensitivity in Shaker Kv Channel
    [Jan 2014]

    Evelyn Martinez-Morales, Dirk J. Snyders, Alain J. Labro. Kv channels detect changes in the membrane potential via their voltage-sensing domains (VSDs) that control the status of the S6 bundle crossing (BC) gate. The movement of the VSDs resul....
    Categories: Journal Articles
  • Dynamics of the Serine Chemoreceptor in the Escherichia coli Inner Membrane: A High-Speed Single-Molecule Tracking Study
    [Jan 2014]

    Dongmyung Oh, Yang Yu, Hochan Lee, Barry L. Wanner, Ken Ritchie. We investigated the mobility of the polar localized serine chemoreceptor, Tsr, labeled by the fluorescent protein Venus in the inner membrane of live Escherichia coli cells at observation r....
    Categories: Journal Articles
  • Protein Arcs May Form Stable Pores in Lipid Membranes
    [Jan 2014]

    Lidia Prieto, Yi He, Themis Lazaridis. Electron microscopy and atomic force microscopy images of cholesterol-dependent cytolysins and related proteins that form large pores in lipid membranes have revealed the presence of incomplete ri....
    Categories: Journal Articles