G. Marius Clore.

Edward W.J. Wallace.

Sebastian Hiller.

Peter J. Hunter.

Martin Bierbaum, Philippe I.H. Bastiaens. The formation of an activity gradient of the small G-protein Ran around chromatin depends on the differential partitioning of the opposing enzyme activities of the Ran guanine nucleotide exchange ....

Benjamin M. Regner, Dejan Vučinić, Cristina Domnisoru, Thomas M. Bartol, Martin W. Hetzer, Daniel M. Tartakovsky, Terrence J. Sejnowski. The crowded intracellular environment poses a formidable challenge to experimental and theoretical analyses of intracellular transport mechanisms. Our measurements of single-particle trajectories ....

Roie Shlomovitz, Lea Fredrickson-Hemsing, Albert Kao, Sebastiaan W.F. Meenderink, Robijn Bruinsma, Dolores Bozovic. Sensitivity of mechanical detection by the inner ear is dependent upon a highly nonlinear response to the applied stimulus. Here we show that a system of differential equations that support a subc....

Enrico Klotzsch, Gerhard J. Schütz. T cell activation is mediated via the recognition of peptides by the T cell receptor (TCR). This receptor ligand interaction is highly specific, and the TCR has to discriminate between a huge numb....

Max Puckeridge, Bogdan E. Chapman, Arthur D. Conigrave, Stuart M. Grieve, Gemma A. Figtree, Philip W. Kuchel. We examined the response of Na+,K+-ATPase (NKA) to monensin, a Na+ ionophore, with and without ouabain, an NKA inhibitor, in suspensions of human erythrocytes (red....

Leiv Øyehaug, Kristian Ø. Loose, Guro F. Jølle, Åsmund T. Røe, Ivar Sjaastad, Geir Christensen, Ole M. Sejersted, William E. Louch. Recent work has demonstrated that cardiomyocyte Ca2+release is desynchronized in several pathological conditions. Loss of Ca2+ release synchrony has been attributed to t-tubu....

Jonathan K. Williams, Yuan Zhang, Klaus Schmidt-Rohr, Mei Hong. The M2 protein of the influenza virus conducts protons into the virion under external acidic pH. The proton selectivity of the tetrameric channel is controlled by a single histidine (His37

Tobias T. Falzone, Patrick W. Oakes, Jennifer Sees, David R. Kovar, Margaret L. Gardel. Dynamic regulation of the actin cytoskeleton is required for diverse cellular processes. Proteins regulating the assembly kinetics of the cytoskeletal biopolymer F-actin are known to impact the ar....

Alan Brown, Christopher J. Robinson, John T. Gallagher, Tom L. Blundell. Fibroblast growth factors (FGFs) utilize cell surface heparan sulfate as a coreceptor in the assembly of signaling complexes with FGF-receptors on the plasma membrane. Here we undertake a complete....

Davide Mercadante, Laurence D. Melton, Geoffrey B. Jameson, Martin A.K. Williams, Alfonso De Simone. The dynamical behavior of biomacromolecules is a fundamental property regulating a large number of biological processes. Protein dynamics have been widely shown to play a role in enzyme catalysis;....

Jordi Silvestre-Ryan, Carlos W. Bertoncini, Robert Bryn Fenwick, Santiago Esteban-Martin, Xavier Salvatella. In the last decade it has become evident that disordered states of proteins play important physiological and pathological roles and that the transient tertiary interactions often present in these ....

Casey O. Diekman, Christopher P. Fall, James D. Lechleiter, David Terman. A mathematical model that integrates the dynamics of cell membrane potential, ion homeostasis, cell volume, mitochondrial ATP production, mitochondrial and endoplasmic reticulum Ca2+ ha....

Tyler Skorczewski, Lindsay Crowl Erickson, Aaron L. Fogelson. Computational simulations using a two-dimensional lattice-Boltzmann immersed boundary method were conducted to investigate the motion of platelets near a vessel wall and close to an intravascular ....

Daniel Jost, Andrzej Nowojewski, Erel Levine. Small regulatory RNAs are central players in the regulation of many cellular processes across all kingdoms of life. Experiments in mouse and human have shown that a typical small RNA may regulate ....

Michał Komorowski, Jacek Miękisz, Michael P.H. Stumpf. Stochasticity is an essential aspect of biochemical processes at the cellular level. We now know that living cells take advantage of stochasticity in some cases and counteract stochastic effects i....

Michael B. Albro, Robert J. Nims, Alexander D. Cigan, Kevin J. Yeroushalmi, Tamara Alliston, Clark T. Hung, Gerard A. Ateshian. It was recently demonstrated that mechanical shearing of synovial fluid (SF), induced during joint motion, rapidly activates latent transforming growth factor β (TGF-β). This discove....