Proceedings of the Natural Academy of Sciences

Proceedings of the National Academy of Sciences RSS feed -- current issue
  • Correction for Tabot et al., Restoring the sense of touch with a prosthetic hand through a brain interface [Correction]
    [Jan 2014]

    NEUROSCIENCE Correction for “Restoring the sense of touch with a prosthetic hand through a brain interface,” by Gregg A. Tabot, John F. Dammann, Joshua A. Berg, Francesco V. Tenore, Jessica L. Boback, R. Jacob Vogelstein, and Sliman J. Bensmaia, which appeared in issue 45, November 5, 2013, of Proc Natl...
    Categories: Journal Articles
  • Correction for Labhsetwar et al., Heterogeneity in protein expression induces metabolic variability in a modeled Escherichia coli population [Correction]
    [Jan 2014]

    SYSTEMS BIOLOGY, CHEMISTRY Correction for “Heterogeneity in protein expression induces metabolic variability in a modeled Escherichia coli population,” by Piyush Labhsetwar, John Andrew Cole, Elijah Roberts, Nathan D. Price, and Zaida A. Luthey-Schulten, which appeared in issue 34, August 20, 2013, of Proc Natl Acad Sci USA (110:14006–14011; first published...
    Categories: Journal Articles
  • Correction for Hong et al., AMPA receptor exchange underlies transient memory destabilization on retrieval [Correction]
    [Jan 2014]

    NEUROSCIENCE Correction for “AMPA receptor exchange underlies transient memory destabilization on retrieval,” by Ingie Hong, Jeongyeon Kim, Jihye Kim, Sukwon Lee, Hyoung-Gon Ko, Karim Nader, Bong-Kiun Kaang, Richard W. Tsien, and Sukwoo Choi, which appeared in issue 20, May 14, 2013, of Proc Natl Acad Sci USA (110:8218–8223; first published...
    Categories: Journal Articles
  • Dynamic Notch interactions with superenhancers [Cell Biology]
    [Jan 2014]

    The main oncogenic driver in T-lymphoblastic leukemia is NOTCH1, which activates genes by forming chromatin-associated Notch transcription complexes. Gamma-secretase-inhibitor treatment prevents NOTCH1 nuclear localization, but most genes with NOTCH1-binding sites are insensitive to gamma-secretase inhibitors. Here, we demonstrate that fewer than 10% of NOTCH1-binding sites show dynamic changes in NOTCH1...
    Categories: Journal Articles
  • Exosomes enhance invasion of GIST [Cell Biology]
    [Jan 2014]

    During tumor development, constant interplay occurs between tumor cells and surrounding stromal cells. We report evidence that gastrointestinal stromal tumor (GIST) cells invade the interstitial stroma through the release of the oncogenic protein tyrosine kinase (KIT)-containing exosomes, which triggers the phenotypic conversion of progenitor smooth muscle cells to tumor-promoting cells....
    Categories: Journal Articles
  • p53 induces AREG for apoptosis by DNA damage [Cell Biology]
    [Jan 2014]

    Upon DNA damage, tumor suppressor p53 determines cell fate by repairing DNA lesions to survive or by inducing apoptosis to eliminate damaged cells. The decision is based on its posttranslational modifications. Especially, p53 phosphorylation at Ser46 exerts apoptotic cell death. However, little is known about the precise mechanism of p53...
    Categories: Journal Articles
  • Levy walk foraging in human hunter-gatherers [Ecology]
    [Jan 2014]

    When searching for food, many organisms adopt a superdiffusive, scale-free movement pattern called a Lévy walk, which is considered optimal when foraging for heterogeneously located resources with little prior knowledge of distribution patterns [Viswanathan GM, da Luz MGE, Raposo EP, Stanley HE (2011) The Physics of Foraging: An Introduction to...
    Categories: Journal Articles
  • Methanotrophs provide N and C for peat moss [Ecology]
    [Jan 2014]

    Nitrogen (N) accumulation rates in peatland ecosystems indicate significant biological atmospheric N2 fixation associated with Sphagnum mosses. Here, we show that the linkage between methanotrophic carbon cycling and N2 fixation may constitute an important mechanism in the rapid accumulation of N during the primary succession of peatlands. In our experimental...
    Categories: Journal Articles
  • Plant functional traits and life histories [Ecology]
    [Jan 2014]

    Ecologists seek general explanations for the dramatic variation in species abundances in space and time. An increasingly popular solution is to predict species distributions, dynamics, and responses to environmental change based on easily measured anatomical and morphological traits. Trait-based approaches assume that simple functional traits influence fitness and life history...
    Categories: Journal Articles
  • Risk mgmt to prevent future WUI fire disasters [Economic Sciences]
    [Jan 2014]

    Recent fire seasons in the western United States are some of the most damaging and costly on record. Wildfires in the wildland-urban interface on the Colorado Front Range, resulting in thousands of homes burned and civilian fatalities, although devastating, are not without historical reference. These fires are consistent with the...
    Categories: Journal Articles
  • Poleward expansion of mangroves [Environmental Sciences]
    [Jan 2014]

    Regional warming associated with climate change is linked with altered range and abundance of species and ecosystems worldwide. However, the ecological impacts of changes in the frequency of extreme events have not been as well documented, especially for coastal and marine environments. We used 28 y of satellite imagery to...
    Categories: Journal Articles
  • Neutral regions to infer human population growth [Genetics]
    [Jan 2014]

    Human populations have experienced dramatic growth since the Neolithic revolution. Recent studies that sequenced a very large number of individuals observed an extreme excess of rare variants and provided clear evidence of recent rapid growth in effective population size, although estimates have varied greatly among studies. All these studies were...
    Categories: Journal Articles
  • HR protects mitosis from replication stress [Genetics]
    [Jan 2014]

    Homologous recombination deficient (HR−) mammalian cells spontaneously display reduced replication fork (RF) movement and mitotic extra centrosomes. We show here that these cells present a complex mitotic phenotype, including prolonged metaphase arrest, anaphase bridges, and multipolar segregations. We then asked whether the replication and the mitotic phenotypes are interdependent. First,...
    Categories: Journal Articles
  • IFITM3 and H7N9 disease [Immunology]
    [Jan 2014]

    A unique avian-origin A/H7N9 influenza virus has so far caused 134 cases with 44 deaths. Probing the host factors contributing to disease severity, we found that lower levels of plasma inflammatory cytokines on hospital admission correlated with faster recovery in 18 patients with A/H7N9 influenza virus, whereas high concentrations of...
    Categories: Journal Articles
  • IRAK-1 regulates rapid NLRP3 activation [Immunology]
    [Jan 2014]

    Pathogenic infections and tissue injuries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1, leading to cleavage of pro-IL-1β and pro-IL-18 and to pyroptosis, a proinflammatory cell death program. Although microbial recognition by Toll-like receptors (TLRs) is known to induce the synthesis of the major caspase-1 substrate pro-IL-1β,...
    Categories: Journal Articles
  • GHRH agonists augment the effect of doxorubicin [Medical Sciences]
    [Jan 2014]

    The dismal prognosis of malignant brain tumors drives the development of new treatment modalities. In view of the multiple activities of growth hormone-releasing hormone (GHRH), we hypothesized that pretreatment with a GHRH agonist, JI-34, might increase the susceptibility of U-87 MG glioblastoma multiforme (GBM) cells to subsequent treatment with the...
    Categories: Journal Articles
  • Pertussis vaccination and infection [Medical Sciences]
    [Jan 2014]

    Pertussis is a highly contagious respiratory illness caused by the bacterial pathogen Bordetella pertussis. Pertussis rates in the United States have been rising and reached a 50-y high of 42,000 cases in 2012. Although pertussis resurgence is not completely understood, we hypothesize that current acellular pertussis (aP) vaccines fail to...
    Categories: Journal Articles
  • ROR1 enhances leukemogenesis in TCL1 mice [Medical Sciences]
    [Jan 2014]

    Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncoembryonic antigen found on chronic lymphocytic leukemia (CLL) B cells, but not on normal adult tissues. We generated transgenic (Tg) mice with human ROR1 regulated by the murine Ig promoter/enhancer. In contrast to nontransgenic littermates, such animals had B-cell–restricted expression of...
    Categories: Journal Articles
  • Exploiting fitness to design therapies for malaria [Microbiology]
    [Jan 2014]

    Drug resistance emerges in an ecological context where fitness costs restrict the diversity of escape pathways. These pathways are targets for drug discovery, and here we demonstrate that we can identify small-molecule inhibitors that differentially target resistant parasites. Combining wild-type and mutant-type inhibitors may prevent the emergence of competitively viable...
    Categories: Journal Articles
  • Gut microbiome mediates airway protection [Microbiology]
    [Jan 2014]

    Exposure to dogs in early infancy has been shown to reduce the risk of childhood allergic disease development, and dog ownership is associated with a distinct house dust microbial exposure. Here, we demonstrate, using murine models, that exposure of mice to dog-associated house dust protects against ovalbumin or cockroach allergen-mediated...
    Categories: Journal Articles